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Related Experiment Video

Updated: Oct 23, 2025

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Accelerated k-space shift calibration for free-breathing stack-of-radial MRI quantification of liver fat and .

Xiaodong Zhong1, Tess Armstrong2,3, Chang Gao2,3

  • 1MR R&D Collaborations, Siemens Medical Solutions USA, Inc, Los Angeles, California, USA.

Magnetic Resonance in Medicine
|August 19, 2021
PubMed
Summary

This study introduces an accelerated k-space shift calibration for free-breathing liver MRI, significantly reducing scan time. The method accurately quantifies proton-density fat fraction (PDFF) and R2* without compromising results.

Keywords:
accelerationk-space shift calibrationproton-density fat fractionquantificationradial MRI

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Area of Science:

  • Medical Imaging
  • Magnetic Resonance Imaging
  • Quantitative MRI

Background:

  • Liver fat quantification using MRI is crucial for disease diagnosis and monitoring.
  • Free-breathing techniques improve patient comfort but often require longer acquisition times.
  • Accurate calibration is essential for reliable proton-density fat fraction (PDFF) and R2* measurements.

Purpose of the Study:

  • To develop and validate an accelerated k-space shift calibration method for free-breathing 3D stack-of-radial MRI.
  • To enable faster and efficient quantification of liver PDFF and R2*.

Main Methods:

  • Developed an accelerated k-space shift calibration by reducing through-plane data acquisition and in-plane averages.
  • Evaluated the method on phantoms and in vivo at 1.5T and 3T using a multi-echo stack-of-radial sequence.
  • Compared results with reference-standard methods using Bland-Altman analysis and Bayesian statistics.

Main Results:

  • Substantial acceleration in both through-plane and in-plane directions was feasible.
  • No significant differences in PDFF and R2* biases or uncertainties were found compared to baseline calibration, except for one specific phantom condition.
  • Achieved a six-fold reduction in equivalent calibration acquisition time (≥80.7% time saving) in vivo.

Conclusions:

  • The proposed accelerated calibration method is feasible for free-breathing stack-of-radial MRI.
  • This technique allows for accelerated PDFF and R2* mapping, improving efficiency in clinical practice.