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Updated: Oct 23, 2025

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection
09:43

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection

Published on: March 30, 2018

9.4K

Two cases of pregnancy after achieving complete remission of chronic active Epstein-Barr virus infection

Nanayo Sasagasako1, Aiko Kakigano1, Chizuko A Kamiya1

  • 1Department of Obstetrics and Gynecology, National Cerebral and Cardiovascular Center, Suita, Japan.

The Journal of Obstetrics and Gynaecology Research
|August 19, 2021
PubMed

Insights

Chronic active Epstein-Barr virus (CAEBV) can cause cardiovascular issues. Pregnant women with CAEBV history need careful cardiovascular monitoring during pregnancy and postpartum for optimal outcomes.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Obstetrics & Gynecology

Background:

  • Chronic active Epstein-Barr virus (CAEBV) infection can manifest with persistent infectious mononucleosis-like symptoms.
  • CAEBV is associated with an increased risk of developing cardiovascular diseases.

Observation:

  • Two pregnant women with histories of CAEBV and pre-existing cardiovascular conditions were studied.
  • One patient experienced decreased left ventricular ejection fraction (LVEF) during pregnancy, necessitating early delivery.
  • The second patient developed superimposed preeclampsia, requiring cesarean section.

Findings:

  • Pregnancy can exacerbate underlying cardiovascular conditions in CAEBV patients.
  • Cardiovascular function, such as LVEF, may improve postpartum.
  • Pulmonary arterial hypertension (PAH) in one patient did not worsen during pregnancy or postpartum.

Implications:

  • Women with CAEBV require thorough preconception cardiovascular evaluations.
  • Close cardiovascular monitoring and management are crucial throughout pregnancy and the postpartum period for CAEBV survivors.
  • This highlights the importance of multidisciplinary care for pregnant women with a history of CAEBV and cardiovascular complications.

Keywords:
cardiovascular diseaseshematologic and clottingmedical problems in pregnancypulmonary

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