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The effects of hyperbaric oxygen therapy (HBOT) on coronavirus disease-2019 (COVID-19): a systematic review

Shahram Oliaei1, SeyedAhmad SeyedAlinaghi2, Mohammad Mehrtak3

  • 1HBOT Research Center, Golestan Hospital, Islamic Republic of Iran, Navy and AJA Medical University, Tehran, Iran.

European Journal of Medical Research
|August 20, 2021
PubMed

Insights

Hyperbaric oxygen therapy (HBOT) appears safe and effective for improving oxygenation in COVID-19 patients. Further research is needed to fully understand its mechanisms and long-term benefits.

Area of Science:

  • Medical Research
  • Pulmonology
  • Infectious Diseases

Background:

  • Oxygenation is critical in COVID-19 treatment.
  • Hyperbaric oxygen therapy (HBOT) is an explored oxygenation method.
  • This review examines HBOT's efficacy and safety in COVID-19 patients.

Purpose of the Study:

  • To systematically review studies on hyperbaric oxygen therapy (HBOT) for COVID-19.
  • To assess the reported efficacy of HBOT in COVID-19 patients.
  • To evaluate adverse events associated with HBOT in COVID-19 treatment.

Main Methods:

  • Systematic search of PubMed, Scopus, Embase, Web of Science, and Cochrane databases up to April 11th, 2021.
  • Two-step screening (title/abstract and full-text) of retrieved records.
  • Quality assessment using the National Institutes of Health (NIH) tool; study registered on PROSPERO.

Main Results:

  • Eight articles from three countries were included, all of good or fair quality.
  • Most studies utilized HBOT sessions under 2 absolute atmospheres (ATA), with initial 90-min sessions decreasing to 60 min.
  • Patients showed recovery and increased blood oxygen saturation following HBOT.

Conclusions:

  • Hyperbaric oxygen therapy (HBOT) shows promise as a safe and effective oxygenation strategy for COVID-19.
  • Limited evidence currently exists regarding HBOT's precise effects and mechanisms in COVID-19.
  • Further extensive, well-designed studies are required to validate these findings.
Abstract

Keywords:
COVID-19Hyperbaric oxygen therapyHyperbaric oxygenationSARS-CoV-2

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