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Reverse remodeling in a heart failure patient with cardiomegaly treated with sacubitril/valsartan: a case report

Yuxin Chen1, Yanqing Wu2

  • 1Department Cardiology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.

Die Pharmazie
|August 20, 2021
PubMed

Insights

Sacubitril/valsartan improved heart function in a patient with heart failure after myocardial infarction. This treatment led to reverse ventricular remodeling and enhanced functional capacity.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Sacubitril/valsartan (S/V) is indicated for heart failure with reduced ejection fraction.
  • It has demonstrated benefits in reducing cardiovascular hospitalizations and mortality.
  • Potential renoprotective and antiarrhythmic effects have also been suggested.

Observation:

  • A patient experienced acute myocardial infarction (AMI) post-percutaneous coronary intervention (PCI).
  • Readmission revealed left heart enlargement and reduced ejection fraction.
  • Guideline-directed medical therapy was initiated, followed by S/V treatment.

Findings:

  • Five months of S/V treatment resulted in reverse ventricular remodeling.
  • Ejection fraction improved by 30%.
  • Left ventricular diastolic diameter reduced by 15 mm, with functional class improving from III to I.

Implications:

  • This case highlights S/V's potential role in promoting reverse ventricular remodeling in post-AMI cardiomegaly.
  • S/V may offer significant benefits beyond its primary indication in specific cardiovascular conditions.
  • Further research into S/V's impact on ventricular remodeling post-myocardial infarction is warranted.

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