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Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research
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[Research progress on regulated necrosis in acute kidney injury]

Yi Lu1, Fangfang Zhou2, Qun Luo2

  • 1School of Medicine, Ningbo University, Ningbo 315000, Zhejiang, China.

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
|August 20, 2021
PubMed

Insights

Regulated necrosis, including necroptosis, pyroptosis, and ferroptosis, is crucial in acute kidney injury (AKI). Understanding these cell death pathways offers new therapeutic targets for AKI treatment.

Area of Science:

  • Cellular biology
  • Pathophysiology
  • Nephrology

Background:

  • Regulated necrosis encompasses necroptosis, pyroptosis, and ferroptosis, representing novel cell death mechanisms.
  • These pathways are implicated in acute kidney injury (AKI) pathogenesis, triggered by ischemia/reperfusion, nephrotoxic drugs, and rhabdomyolysis.

Purpose of the Study:

  • To review the signaling pathways of necroptosis, pyroptosis, and ferroptosis.
  • To summarize current research on the role of regulated necrosis in AKI.
  • To identify potential therapeutic targets for AKI prevention and treatment.

Main Methods:

  • Literature review of regulated necrosis pathways.
  • Analysis of research progress in AKI related to cell death.
  • Synthesis of findings to identify therapeutic targets.

Main Results:

  • Detailed overview of necroptosis, pyroptosis, and ferroptosis signaling.
  • Evidence linking these pathways to AKI development and progression.
  • Identification of key molecular players within these pathways relevant to AKI.

Conclusions:

  • Regulated necrosis pathways are integral to AKI.
  • Targeting necroptosis, pyroptosis, and ferroptosis presents promising therapeutic strategies for AKI.
  • Further research into these pathways can elucidate AKI pathogenesis and guide treatment development.

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