Mean differences in maternal body mass index and recurrent pregnancy loss: a systematic review and meta-analysis of
Abey Eapen1, Emily T Hayes2, Dana B McQueen3
1Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Carver College of Medicine, University of Iowa, Iowa City, Iowa.
Objective:
To investigate the association of maternal body mass index (BMI) and recurrent pregnancy loss (RPL).
Design:
Systematic review and meta-analysis.
Setting:
Not applicable.
Patient(S):
A total of 3,833 women with RPL and 4,083 women as controls.
Intervention(S):
Studies were identified through a search of PubMed, Embase, Scopus, and Cochrane.
Main Outcome Measure(S):
The primary outcome of interest was RPL using the mean differences in maternal BMI as the predictor variable. The results of the meta-analysis were reported as the mean difference with a 95% confidence interval.
Result(S):
In total, 892 studies were reviewed. Pooled data from 25 studies suggested that the maternal BMI of women with a history of recurrent pregnancy loss was significantly higher than the BMI of controls, mean difference 0.7 kg/m2 [95% confidence interval 0.2-1.3].
Conclusion(S):
These findings supported an association between maternal BMI and RPL. Large prospective studies are needed to evaluate the influence of maternal BMI on pregnancy outcomes in women with RPL.
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