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Regenerating dynamic organs using biomimetic patches.

Parth Chansoria1, Emma L Etter1, Juliane Nguyen1

  • 1Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Trends in Biotechnology
|August 20, 2021
PubMed
Summary
This summary is machine-generated.

New anisotropic and auxetic patches mimic dynamic organ biomechanics, addressing challenges in regenerative medicine. These biomimetic patches offer improved durability and applicability for organ regeneration therapies.

Keywords:
anisotropicauxeticnegative Poisson’s ratiopatchregenerationtissue engineering

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Regenerating dynamic organs is difficult due to their anisotropic nature and large deformations.
  • Existing regenerative medicine approaches face durability and applicability challenges.
  • Organ dynamics, including anisotropy and volumetric changes, complicate tissue regeneration.

Purpose of the Study:

  • To review design, material, and processing considerations for biomimetic patches.
  • To summarize advances in anisotropic and auxetic patches for dynamic organ regeneration.
  • To discuss challenges and opportunities for clinical translation of patch-based therapeutics.

Main Methods:

  • Literature review of biomimetic patches for organ regeneration.
  • Analysis of design, material, and processing factors influencing patch biomechanics.
  • Synthesis of recent advancements in anisotropic and auxetic patch technology.

Main Results:

  • Anisotropic and auxetic properties are critical for mimicking native tissue biomechanics.
  • Biomimetic patches can accommodate large volumetric deformations in dynamic organs.
  • Optimal patch design depends on target pathology and desired biomechanical properties.

Conclusions:

  • Biomimetic patches show promise for overcoming challenges in dynamic organ regeneration.
  • Addressing current challenges could expand applications and expedite clinical translation.
  • Further research into patch design, materials, and processing is needed for therapeutic success.