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[Antimalaria therapy of chronic renal failure]
Kanga Sita N'Zoue1, Simeon Yobo-Bi Manan1, Yves Cedrick Kee Mankoh1
1Service de pharmacologie clinique, Département de bioclinique et sciences fondamentales, centre hospitalier universitaire Bouaké, UFRSMB, université Alassane-Ouattara, 01 BPV 18, Bouaké 01, Côte d'Ivoire.
Nephrologie & Therapeutique
|August 20, 2021
Summary
Treatment of malaria in chronic renal failure patients showed deviations from national guidelines. Parenteral antimalarials were preferred due to severe anemia, despite not always following recommended protocols.
Area of Science:
- Nephrology
- Infectious Diseases
- Pharmacology
Background:
- Malaria treatment is complex in chronic renal failure (CRF) patients due to immune abnormalities.
- CRF patients face a higher risk of severe illness and complications from malaria.
Purpose of the Study:
- To describe the malaria treatment profile in patients with chronic renal failure.
- To assess adherence to national malaria treatment guidelines in this population.
Main Methods:
- Retrospective study of CRF patients with malaria from October 2018 to February 2019.
- Data collected on demographics, clinical signs, malaria confirmation, treatment regimens, and outcomes.
- Included patients admitted to nephrology departments of university hospitals.
Main Results:
- 40 out of 278 (14.4%) CRF patients had malaria; 87.5% were stage 5 CRF, 85% on dialysis.
- Common symptoms included hyperthermia (70%) and severe anemia (average Hb 7.1g/dL).
- Antimalarial treatment often involved artemether/artesunate via injection (67.5%), with 78% lacking oral relay; national guidelines were not followed.
Conclusions:
- A misuse of antimalarials was observed, with national recommendations not being respected.
- Severe anemia in CRF patients may necessitate parenteral antimalarial routes.
- Adherence to established treatment protocols is crucial for effective malaria management in CRF patients.
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