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Updated: Oct 23, 2025

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Bullous fixed drug eruption following administration of the recombinant adjuvant Shingrix vaccine
Hallie Thompson1, Laura Nichols2, Tania Gonzalez Santiago2
1University of North Dakota, Edgeley, North Dakota, USA hallie.b.anderson@und.edu.
Abstract:
A 51-year-old woman with Crohn's disease presented with a bullous rash on her left arm and axilla 2 days after receiving her second dose of the recombinant adjuvant Shingrix vaccine. PCR for herpes simplex virus (HSV) 1, HSV 2 and varicella zoster virus was negative. Punch biopsy revealed changes that were consistent with a bullous fixed drug eruption. She was successfully treated oral prednisone and topical triamcinolone cream. This is the first known case of a bullous fixed drug eruption due to the recombinant adjuvant Shingrix vaccine.
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