Related Experiment Video
Updated: Oct 23, 2025

05:03
Brain Death Induction in Mice Using Intra-Arterial Blood Pressure Monitoring and Ventilation via Tracheostomy
Published on: April 17, 2020
5.7K
Building a Fence Around Brain Death: The Shielded-Brain Formulation
1From the University of Michigan, Ann Arbor, MI. dgelb@umich.edu.
Neurology
|August 20, 2021
Summary
Brain death, established over 50 years ago, continues to cause confusion and debate. This article reviews its history and philosophical basis, proposing a new formulation to address objections and maintain current practices.
Area of Science:
- Neurology
- Medical Ethics
- Legal Medicine
Background:
- The concept of brain death, established over five decades ago, is integral to legal and clinical practice.
- Despite its widespread adoption, brain death remains a subject of significant confusion, debate, and legal challenges.
- Variability in clinical standards and policy controversies have prompted a review of the Uniform Determination of Death Act (UDDA).
Purpose of the Study:
- To review the historical development and philosophical foundations of the brain death concept.
- To summarize existing objections to current philosophical formulations of brain death.
- To propose a revised formulation that resolves these objections while upholding established clinical practices.
Main Methods:
- Historical review of brain death concept and its philosophical underpinnings.
- Analysis of objections raised against prevailing philosophical formulations.
- Development of a new formulation addressing identified objections.
Main Results:
- The article traces the evolution of brain death criteria and their ethical and legal implications.
- Key philosophical objections to the current understanding of brain death are identified and discussed.
- A novel philosophical framework is presented to reconcile controversies and support existing medical practices.
Conclusions:
- The concept of brain death requires re-evaluation due to persistent controversies and variability.
- The proposed new formulation offers a resolution to philosophical objections, aiming to enhance clarity and consistency.
- This work supports the preservation of current clinical standards for determining death while addressing ongoing debates.

