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Understanding fatigue in progressive supranuclear palsy.
Jong Hyeon Ahn1,2, Joomee Song1,2, Dong Yeong Lee1,2
1Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Republic of Korea.
Scientific Reports
|August 20, 2021
Summary
Fatigue is common in patients with progressive supranuclear palsy (PSP), affecting nearly 40%. It is linked to other non-motor symptoms and reduced quality of life, highlighting the need for better understanding and management strategies.
Area of Science:
- Neurology
- Clinical Neuroscience
Background:
- Fatigue is a prevalent non-motor symptom (NMS) in Parkinson's disease (PD).
- Understanding fatigue in progressive supranuclear palsy (PSP) is limited.
- This study explores fatigue's association with clinical features and NMS in PSP patients.
Purpose of the Study:
- To investigate the prevalence and characteristics of fatigue in probable PSP patients.
- To examine the relationship between fatigue, other NMS, and quality of life in PSP.
Main Methods:
- 72 probable PSP patients were assessed.
- Fatigue was measured using the Parkinson Fatigue Scale (PFS).
- Clinical features and NMS were evaluated using PSPRS, BDI, MMSE, FAB, PDSS, NMSS, PDQ-39 SI, and SCOPA-AUT.
Main Results:
- Fatigue prevalence was 38.9% (28/72) in PSP patients.
- Primary fatigue group showed higher PDQ-39 SI than non-fatigue group.
- Secondary fatigue group had higher NMSS, PDQ-39 SI, and SCOPA-AUT scores; PFS correlated positively with NMSS, PDQ-39 SI, and SCOPA-AUT.
Conclusions:
- Fatigue is a common and significant issue in PSP patients.
- Fatigue is associated with other NMS and impacts quality of life.
- Findings offer insights into managing fatigue in PSP.
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