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Multiple endocrine neoplasia 1: a broad overview.
Rachel Thompson1, Christine S Landry2
1Department of Surgery, Baylor University Medical Center, Dallas, TX, USA.
Therapeutic Advances in Chronic Disease
|August 20, 2021
Summary
Multiple Endocrine Neoplasia type 1 (MEN1) involves tumors in the pancreas, pituitary, and parathyroid glands. This review covers MEN1 diagnosis, manifestations, treatment, and surveillance strategies for these common and less common tumors.
Area of Science:
- Endocrinology
- Oncology
- Genetics
Background:
- Multiple Endocrine Neoplasia type 1 (MEN1) is a rare genetic disorder.
- MEN1 is characterized by the development of tumors in endocrine glands.
- Key affected glands include the pancreas, pituitary, and parathyroid.
Purpose of the Study:
- To provide a comprehensive overview of MEN1.
- To detail the diagnostic approaches for MEN1-associated tumors.
- To outline current treatment and surveillance protocols for MEN1 patients.
Main Methods:
- Review of existing literature on MEN1.
- Synthesis of diagnostic criteria and clinical guidelines.
- Analysis of treatment outcomes and surveillance recommendations.
Main Results:
- Common MEN1 tumors arise in the pancreas, pituitary, and parathyroid glands.
- Less common tumors include lung/thymus neuroendocrine tumors, adrenal tumors, and cutaneous lesions.
- Early diagnosis and consistent surveillance are crucial for managing MEN1.
Conclusions:
- MEN1 management requires a multidisciplinary approach.
- Timely diagnosis and appropriate treatment can improve patient outcomes.
- Ongoing surveillance is essential for detecting and managing MEN1-related neoplasms.
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