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Sequestosome 1/p62: A multitasker in the regulation of malignant tumor aggression (Review)

Jinlong Tang1, Yuan Li2, Shuli Xia3,4

  • 1Department of Pathology and Oncology, Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China.

International Journal of Oncology
|August 20, 2021
PubMed

Insights

Sequestosome 1 (SQSTM1)/p62 is a versatile adapter protein regulating cell death, growth, and metastasis. It acts as a proto-oncogene or tumor suppressor, impacting cancer progression and patient outcomes.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Cancer Research

Background:

  • Sequestosome 1 (SQSTM1)/p62 is an adapter protein crucial for protein degradation pathways, including autophagy and the ubiquitin-proteasome system.
  • SQSTM1/p62 plays multifaceted roles in cellular processes, influencing genetic stability, post-transcriptional regulation, and protein function.

Purpose of the Study:

  • To elucidate the comprehensive regulatory functions of SQSTM1/p62 in cancer.
  • To understand how SQSTM1/p62's molecular structure influences signaling pathways and tumor behavior.

Main Methods:

  • Literature review and analysis of existing studies on SQSTM1/p62.
  • Examination of SQSTM1/p62's involvement in various cancer hallmarks and signaling pathways.

Main Results:

  • SQSTM1/p62 is a critical regulator of tumor cell genetic stability, autophagy, apoptosis, proliferation, migration, invasion, metastasis, and response to therapy.
  • Its distinct molecular structure enables participation in diverse signaling pathways, including positive feedback loops and epithelial-mesenchymal transition (EMT).
  • SQSTM1/p62 functions as both a proto-oncogene and a tumor suppressor, influencing tumor aggression and patient prognosis.

Conclusions:

  • SQSTM1/p62 is a pivotal protein with significant implications for cancer development, progression, and therapeutic strategies.
  • Understanding SQSTM1/p62's dual role is essential for predicting patient prognosis and developing targeted cancer treatments.
Keywords:
EMTSQSTM1/p62autophagytumorubiquitin‑proteasome degradation

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