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Updated: Oct 23, 2025

An Open-Source Normothermic Perfusion System Designed for Research Scientists

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Published on: July 18, 2025

Characterizing and Tuning Perfusion Parameters Within an Innovative, Versatile Oxygenating Perfusion System.

Daniel J Portillo¹, Lauren Bayliss^2,3, Stephen Rivas¹

¹Department of Mechanical Engineering, The University of Texas at San Antonio, 1 UTSA Circle, San Antonio, TX, 78249, USA.

Annals of Biomedical Engineering

|August 20, 2021

Summary

A new portable device delivers oxygenated and pulsatile perfusion using a single pump-oxygenator. This novel system effectively supports tissue preservation and resuscitation applications.

Keywords:

Bioreactor Closed-loop resuscitation Heart preservation Kidney preservation Liver preservation Machine perfusion Organ preservation Tissue preservation

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Porcine Normothermic Isolated Liver Perfusion

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Porcine Normothermic Isolated Liver Perfusion

Porcine Normothermic Isolated Liver Perfusion

Published on: June 9, 2023

Area of Science:

Biomedical Engineering
Physiology
Transplantation Science

Background:

Oxygenated perfusion is crucial for improving tissue preservation in transplantation, bioreactor applications, and resuscitation.
Existing methods for oxygenated perfusion can be complex and lack portability.

Purpose of the Study:

To develop and characterize a novel, portable device for oxygenated and pulsatile perfusion.
To evaluate the device's performance across various physiological conditions mimicking different organs.

Main Methods:

A single pump-oxygenator component with cyclically inflated/deflated silicone tubes was designed.
Pump variables (oxygen pressure, tube length) were tested against hydraulic models of kidney, liver, and heart vascular resistance.
Perfusion pressures, flow rates, and oxygenation rates were measured and pulse rates optimized.

Main Results:

The device achieved perfusion pressures from 3.5 to 109 mmHg and flow rates from 1.4 to 71.8 mL/min.
Oxygenation rates reached up to 316.6 µmol/min.
The device demonstrated capability to meet parameters used in prior kidney, liver, and heart preservation studies.

Conclusions:

A novel portable device effectively provides regulated oxygenated and pulsatile perfusion.
The device's performance is tunable and suitable for diverse applications including organ preservation and resuscitation.
This technology offers a promising solution for advanced tissue perfusion needs.