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Automated Preparation of [68Ga]Ga-3BP-3940 on a Synthesis Module for PET Imaging of the Tumor Microenvironment
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PEG-Polymer Encapsulated Aggregation-Induced Emission Nanoparticles for Tumor Theranostics
Jun Dai1, Xiaoqi Dong2, Quan Wang2
1Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, 430032, China.
Advanced Healthcare Materials
|August 20, 2021
Summary
Aggregation-induced emission luminogens (AIEgens) overcome fluorescence quenching for enhanced tumor imaging and therapy. Encapsulating AIEgens in polyethylene glycol (PEG)-polymers creates nanoparticles (NPs) with improved biological applications.
Area of Science:
- Biomedical Engineering
- Materials Science
- Nanotechnology
Background:
- Aggregation-caused quenching (ACQ) of fluorescent dyes limits their use in high concentrations for tumor imaging and therapy.
- Aggregation-induced emission luminogens (AIEgens) offer a promising alternative, exhibiting enhanced fluorescence quantum yield, photobleaching resistance, and photosensitivity.
Purpose of the Study:
- To address the challenge of ACQ in fluorescent tumor imaging and therapy.
- To explore the potential of AIEgens and their encapsulation in polyethylene glycol (PEG)-polymers for improved nanoparticle (NP) development.
Main Methods:
- Utilized AIEgens to overcome the ACQ effect inherent in traditional fluorescent dyes.
- Employed polyethylene glycol (PEG)-polymer encapsulation to create nanoparticles (NPs) for hydrophobic AIEgens.
- Modified PEG-polymers with bioactive functional groups to enhance NP biological effects.
Main Results:
- AIEgens demonstrated superior fluorescence properties compared to ACQ-prone dyes.
- PEG-polymer encapsulation effectively addressed the hydrophobicity of AIEgens, facilitating their application in biological systems.
- Functionalized PEG-polymers enhanced the biological efficacy of the developed NPs.
Conclusions:
- The combination of AIEgens and PEG-polymers presents a novel and effective strategy for tumor imaging and therapy.
- This approach overcomes key limitations of traditional fluorescent agents, showing significant promise for clinical translation.
