Related Experiment Video
Updated: Oct 23, 2025

Novel Methods for Intranasal Administration Under Inhalation Anesthesia to Evaluate Nose-to-Brain Drug Delivery
Published on: November 14, 2018
A Recent Update on Intranasal Delivery of High Molecular Weight Proteins, Peptides, and Hormones
Mayank Sharma1, Simran Waghela1, Riddhi Mhatre1
1Departement of Pharmaceutics, SVKM's NMIMS, School of Pharmacy and Technology Management, NMIMS Shirpur Campus, Maharashtra, India.
Abstract:
Proteins and hormones have a wide range of therapeutic uses that have emerged throughout the years. The increase in their clinical application nowadays has outgrown the need to deliver these macromolecules without deterioration. This is where the nasal route of delivery has proven to be the most helpful tool in providing ease of administration. Despite the obstacles, smart polymers, nasal enhancers, nanotechnology-based delivery systems, and computational modeling tools have all been used to increase the nasal route's residence time and absorption window. This review highlights the systemic delivery of macromolecules such as protein and hormones, which can also be delivered via nose-to-brain through various transportation pathways. This strategy has proved beneficial in treating several neurological disorders like brain tumors, Alzheimer's, Ischemic stroke, etc. Except for the marketed preparation and patents, several other drugs are still under clinical trials. We also like to conclude that many of the newer proteins and hormones are still under developmental stages, for which nasal delivery will be a boon in administering these newer molecules.
More Related Videos
07:28Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
Published on: April 6, 2017
07:33Preparation, Characteristics, Toxicity, and Efficacy Evaluation of the Nasal Self-Assembled Nanoemulsion Tumor Vaccine In Vitro and In Vivo
Published on: September 28, 2022
Related Concept Videos
Drug Delivery: Miscellaneous Routes
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Additional Routes of Drug Administration
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
Drug Delivery: Parenteral Route
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
Inhaled Medications
Drug Delivery: Overview
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Routes of Drug Administration: Parenteral
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...