Related Experiment Video

Updated: Oct 23, 2025

Transuterine Fetal Tracheal Occlusion Model in Mice
06:31

Transuterine Fetal Tracheal Occlusion Model in Mice

Published on: February 5, 2021

3.3K

Survival outcomes of very low birth weight infants with trisomy 18

Hirosuke Inoue1,2, Yuka Matsunaga1,2, Toru Sawano1,2

  • 1Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

American Journal of Medical Genetics. Part A
|August 20, 2021
PubMed

Insights

Trisomy 18 (T18) infants born with very low birth weight (VLBW) had higher rates of esophageal atresia and surgery. However, VLBW did not significantly impact one-year survival rates for T18 infants receiving active interventions.

Area of Science:

  • Genetics
  • Neonatalogy
  • Pediatric Surgery

Background:

  • Trisomy 18 (T18) is a common aneuploidy associated with poor survival.
  • The combined risk of T18 and very low birth weight (VLBW) is not well understood.
  • VLBW is defined as a birth weight less than 1500 grams.

Purpose of the Study:

  • To investigate the survival and clinical features of infants with Trisomy 18 and very low birth weight.
  • To compare outcomes between VLBW and non-VLBW infants with T18.

Main Methods:

  • Observational cohort study of infants with T18 admitted to Kyushu University Hospital (2000-2019).
  • Data collected on gestational age, birth weight, clinical features, interventions, and survival.
  • Comparison of clinical characteristics and survival rates between VLBW and non-VLBW T18 infants.

Main Results:

  • Of 30 T18 infants, 11 (37%) were VLBW.
  • VLBW infants had lower gestational age (34.4 vs. 39.4 weeks) and higher incidence of esophageal atresia (64% vs. 11%).
  • VLBW infants underwent more surgeries (55% vs. 5%) and positive pressure ventilation (82% vs. 32%).
  • One-year survival rates did not differ significantly (45% vs. 26%).

Conclusions:

  • Very low birth weight may not be a fatal factor for Trisomy 18 infants who receive active medical and surgical interventions.
  • Active management strategies can improve outcomes for VLBW infants with T18.
  • Further research is needed to optimize care for this vulnerable population.

Keywords:
active interventionlong-termlow birth weight infantsmortalitytrisomy 18

More Related Videos

A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis06:19

A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis

Published on: January 7, 2018

10.6K
Model Surgical Training: Skills Acquisition in Fetoscopic Laser Photocoagulation of Monochorionic Diamniotic Twin Placenta Using Realistic Simulators09:51

Model Surgical Training: Skills Acquisition in Fetoscopic Laser Photocoagulation of Monochorionic Diamniotic Twin Placenta Using Realistic Simulators

Published on: March 21, 2018

19.9K

Related Concept Videos

Truncation in Survival Analysis01:09

Truncation in Survival Analysis

Truncation in survival analysis refers to the exclusion of individuals or events from the dataset based on specific criteria related to the time of the event. This exclusion can happen in two primary forms: left truncation and right truncation.
Left truncation occurs when individuals who experienced the event of interest before a certain time are not included in the study. This is often due to a "delayed entry" into the study where only those who survive until a certain entry point are...
350
Meiosis I01:49

Meiosis I

Meiosis is a carefully orchestrated set of cell divisions, the goal of which—in humans—is to produce haploid sperm or eggs, each containing half the number of chromosomes present in somatic cells elsewhere in the body. Meiosis I is the first such division, and involves several key steps, among them: condensation of replicated chromosomes in diploid cells; the pairing of homologous chromosomes and their exchange of information; and finally, the separation of homologous chromosomes by...
198.3K
Meiosis vs. Mitosis02:57

Meiosis vs. Mitosis

Cell division is necessary for growth and reproduction in organisms. Mitosis aids cell growth and development by dividing somatic cells. In contrast, meiosis causes the division of germ cells and plays an essential role in sexual reproduction. Due to their unique functional requirements, mitosis and meiosis differ from each other in multiple aspects.
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...
62.5K
Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
3.1K