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Roles of NPAS2 in circadian rhythm and disease

L U Peng1, Gaigai Bai1, Yingxin Pang1

  • 1Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan 250012, China.

Acta Biochimica Et Biophysica Sinica
|August 20, 2021
PubMed

Insights

The circadian rhythm gene NPAS2 plays a key role in tumorigenesis. Variations in NPAS2 impact cancer patient survival and outcomes, highlighting its clinical potential.

Area of Science:

  • Genetics and Molecular Biology
  • Chronobiology
  • Cancer Research

Background:

  • NPAS2, a circadian rhythm gene, encodes neuronal PAS domain protein 2.
  • It interacts with DNA at E-box sequences and heterodimerizes with BMAL1.
  • NPAS2 is implicated in various diseases, particularly tumorigenesis.

Purpose of the Study:

  • To review recent advances in understanding NPAS2.
  • To highlight its potential clinical applications and future prospects in disease, especially cancer.

Main Methods:

  • Literature review of NPAS2 research.
  • Analysis of NPAS2's role in cellular functions and disease progression.
  • Examination of NPAS2's association with patient survival and outcomes.

Main Results:

  • NPAS2 variations affect overall survival and mortality risk in cancer patients.
  • Differential NPAS2 expression correlates with patient outcomes in breast cancer, lung cancer, and non-Hodgkin's lymphoma.
  • NPAS2 exhibits complex cellular functions relevant to disease.

Conclusions:

  • NPAS2 is a significant factor in cancer development and progression.
  • Understanding NPAS2's role offers potential for novel clinical strategies.
  • Further research into NPAS2 is warranted for therapeutic development.
Keywords:
SNPfunctionneuronal PAS domain protein 2 (NPAS2)structure

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