Related Experiment Video
Updated: Oct 23, 2025
Anti-Nuclear Antibody Screening Using HEp-2 Cells
Published on: June 23, 2014
Anti-Golgi Antibody as a Potential Indicator for Rheumatoid Arthritis
Jianzhao Zhai1, Jing Liao1, Minjin Wang1
1West China School of Medicine/Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.
Objective:
To reveal the relationship between anti-Golgi antibody (AGA) and clinical diseases through retrospective analysis.
Methods:
The clinical data of 584 cases testing positive for AGA in the past 11 years were collected and retrospectively analyzed.
Results:
AGA pattern accounted for .2% of positive ANA results. In total, 35.0% of diagnosed patients had autoimmune diseases (AID), mainly rheumatoid arthritis (RA). High-titer AGA (≧1:1000) was common in AID. In nondiagnosed patients with clinical symptoms, joint pain/muscle pain was the most common.
Conclusions:
Positive AGA with high titer was closely related to RA. Joint pain/muscle pain was the most common symptom in patients who tested AGA positive. Therefore, AGA may be a key indicator of RA in the Chinese population.
More Related Videos
10:16Generation of Two-color Antigen Microarrays for the Simultaneous Detection of IgG and IgM Autoantibodies
Published on: September 15, 2016
10:27Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
Published on: December 15, 2011
Related Concept Videos
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
01:11Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
01:15Myasthenia Gravis: Diagnostic Tests
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...