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Risk factors for intracranial aneurysm rupture in pediatric patients

Ruiqi Chen1, Si Zhang1, Anqi Xiao1

  • 1Department of Neurosurgery, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu, 610041, Sichuan, China.

Acta Neurochirurgica
|August 20, 2021
PubMed

Insights

Pediatric intracranial aneurysms (IAs) pose a fatal risk. Children under 5 and IAs in the distal arterial region (DAR) are key rupture risk factors, while wide-necked IAs offer protection.

Area of Science:

  • Neurology
  • Pediatric Medicine
  • Vascular Surgery

Background:

  • Intracranial aneurysms (IAs) are rare but fatal in children.
  • Risk factors for IA rupture in adults are known, but unknown in pediatric patients.

Purpose of the Study:

  • To identify risk factors for intracranial aneurysm rupture in pediatric patients.
  • To elucidate the characteristics of pediatric intracranial aneurysms associated with rupture.

Main Methods:

  • Retrospective analysis of 94 pediatric patients with intracranial aneurysms.
  • Division of patients into ruptured and unruptured groups.
  • Univariable and multiple logistic regression analyses to identify risk factors.

Main Results:

  • Age under 5 years (OR=6.844, P=0.042) and location in the distal arterial region (DAR) (OR=4.162, P=0.029) were independent risk factors for rupture.
  • Wide-necked aneurysms (OR=0.235, P=0.047) were independently associated with a lower risk of rupture.
  • Giant aneurysms and those in the internal carotid artery were more common in the unruptured group.

Conclusions:

  • Younger age (0-5 years) and distal arterial region (DAR) location are independent risk factors for pediatric intracranial aneurysm rupture.
  • Wide-necked intracranial aneurysms are associated with a reduced risk of rupture in pediatric patients.
  • Findings aid in risk stratification and management of pediatric intracranial aneurysms.
Abstract

Keywords:
Distal arterial regionPediatric intracranial aneurysmsRisk factorsRupture

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