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Updated: Oct 23, 2025
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Anterior Segment Organ Culture Platform for Tracking Open Globe Injuries and Therapeutic Performance
Published on: August 25, 2021
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Global Current Practice Patterns for the Management of Open Globe Injuries
Sarah C Miller1, Michael J Fliotsos1, Grant A Justin2
1Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
American Journal of Ophthalmology
|August 20, 2021
Summary
Global management of open globe injuries shows significant variation in antibiotic use and patient observation practices. Evidence-based international guidelines are needed to standardize care for these serious eye injuries.
Area of Science:
- Ophthalmology
- Trauma Surgery
- Global Health
Background:
- Open globe injuries represent a significant cause of vision loss worldwide.
- Current management strategies for these injuries lack global standardization.
Purpose of the Study:
- To determine current global practice patterns for managing open globe injuries.
- To identify variations in treatment approaches among international eye trauma centers.
Main Methods:
- A cross-sectional online survey was conducted from August 2020 to January 2021.
- Experts at global eye trauma centers managing at least one open globe injury monthly responded.
- The survey assessed antibiotic and steroid use, procedural decisions, imaging, and admission practices.
Main Results:
- Responses were received from 33 institutions across North America, Asia, South America, Africa, Europe, and Australia.
- Preoperative systemic antibiotics were used by 75.8% of institutions, with variations in topical and intraoperative antibiotic use.
- Postoperative systemic antibiotics (69.7%) and topical steroids (87.9%) were common, but specific choices differed. Admission practices also varied, with 54.5% routinely admitting patients post-repair.
Conclusions:
- Significant global variation exists in the preferred management of open globe injuries.
- The development of evidence-based international guidelines is crucial for optimizing patient care and standardizing treatment.
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