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Vaccinations01:51

Vaccinations

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Update on Influenza Vaccines: Needs and Progress.

Richard B Kennedy1, Inna G Ovsyannikova1, Gregory A Poland1

  • 1Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, Minn.

The Journal of Allergy and Clinical Immunology. in Practice
|August 20, 2021
PubMed
Summary
This summary is machine-generated.

Annual influenza epidemics pose a global health threat. This review covers current vaccines, their limitations, and the development of broadly protective, universal influenza vaccines for better control.

Keywords:
EpidemicInfluenzaInfluenza vaccinesPandemicRespiratory disease

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Area of Science:

  • Immunology
  • Epidemiology
  • Vaccinology

Background:

  • Influenza remains a significant global public health concern, causing substantial morbidity and mortality annually and during pandemics.
  • Despite decades of vaccine availability, challenges like variable vaccine effectiveness, viral evolution (antigenic drift and shift), and vaccine hesitancy persist.
  • Current influenza vaccines, while beneficial, necessitate continuous improvement to effectively combat the evolving virus.

Purpose of the Study:

  • To review the current landscape of influenza vaccines.
  • To address existing safety concerns associated with influenza vaccines.
  • To discuss the ongoing research and development of next-generation influenza vaccines, including universal and broadly protective options.

Main Methods:

  • Literature review of current influenza vaccine technology.
  • Analysis of vaccine effectiveness data and safety profiles.
  • Exploration of strategies for developing universal influenza vaccines.

Main Results:

  • Current influenza vaccines face limitations in effectiveness and broad protection against diverse strains.
  • Ongoing research focuses on overcoming viral evasion mechanisms and enhancing vaccine immunogenicity.
  • Development of universal influenza vaccines aims to provide long-lasting protection against multiple strains and subtypes.

Conclusions:

  • Newer influenza vaccines with higher efficacy are crucial for better disease control.
  • Universal influenza vaccines represent a promising strategy to address the limitations of current vaccines.
  • Continued innovation in vaccinology is essential to mitigate the global impact of influenza.