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Updated: Oct 23, 2025

Feeder-free Derivation of Melanocytes from Human Pluripotent Stem Cells
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Human embryonic stem cell-derived melanocytes exhibit limited immunogenicity

Jinqi Wang1, Xuanhao Zeng1, Yating Liu1

  • 1Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, 200040, China.

Biochemical and Biophysical Research Communications
|August 20, 2021
PubMed

Although surgical interventions have become optional for refractory vitiligo, grafting related injuries is inevitable. Embryonic stem cell (ESC) derivatives can be used in transplantation to address this issue, but the immune rejection due to allogeneic transplantation is of great concern. To investigate the immunogenicity of ESC derived melanocytes (ES-MC), we established a co-culture system of ES-MC and allogeneic PBMC. The results showed that ES-MC were similar to human primary melanocytes, with low expression of immune related molecules, and limited capability of stimulating allogeneic lymphocytes in vitro. Taken together, our findings confirm that ES-MC are of limited immunogenicity, providing new insights into the application of ES-MC in the regenerative medicine such as treating vitiligo.

Keywords:
Embryonic stem cellsImmunogenicityMelanocyteRegenerative medicineVitiligo

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