Cognitive fatigue interventions for people with multiple sclerosis: A scoping review

Fatigue is a common symptom experienced by people with multiple sclerosis (MS) and can be categorized as physical or cognitive fatigue. The existing body of literature mostly focuses on physical fatigue in MS and there is limited research on cognitive fatigue and interventions to effectively manage cognitive fatigue in this cohort. Therefore, the aim of this scoping review is to identify and summarize available research literature about different types of interventions to manage cognitive fatigue to provide a comprehensive perspective on treatment options.

The PRISMA Extension for Scoping Reviews methodology was used. Searches were conducted in May 2021 in the following databases: CINAHL Plus with Full Text, MEDLINE via Ovid, PsycINFO, Embase via Ovid, and ProQuest Dissertations and Theses Global. The inclusion criteria were: peer-reviewed journal articles written in English or French that included an intervention to manage MS cognitive fatigue. Search keywords included multiple sclerosis, cognitive fatigue, and intervention. All retrieved citations' titles and abstracts were screened, and eligible articles were fully reviewed by two reviewers. The included studies were categorized based on the type of intervention, and effect size were calculated to estimate the effectiveness of the interventions.

Of 653 retrieved citations, 34 were retained for this review. Participants of the included studies were mostly middle-aged adults with relapsing-remitting MS, without severe mobility issues, who were living with MS for about 10 years on average. The majority of studies were randomized controlled trials (n = 17), followed by pilot and feasibility trials (n = 4), case-control (n = 2), and other experimental designs (n = 11). The interventions were categorized as educational programs (such as self-management programs, diet, and counselling) (n = 18), medical and pharmacological (such as monoaminergic stabilizers, natalizumab, and dalfampridine) (n = 6), and exercise and physical interventions (such as resistance training, aquatic exercise, and walking) (n = 10). Of the included interventions, fatigue self-management interventions that incorporate educational materials and involve trained facilitators seem to be optimal for reducing the negative effects of cognitive fatigue.

This review identified a variety of interventions for MS cognitive fatigue management. However, there is not sufficient evidence leading to a clear recommendation about appropriate and effective approaches for cognitive fatigue management. More research in this field is needed.