Cognitive fatigue interventions for people with multiple sclerosis: A scoping review

Area of Science:

• Neurology
• Rehabilitation Science
• Clinical Psychology

Background:

• Cognitive fatigue is a prevalent and debilitating symptom in multiple sclerosis (MS).
• Existing research predominantly addresses physical fatigue, with limited focus on cognitive fatigue and its management.
• This scoping review addresses the gap by exploring interventions for cognitive fatigue in MS.

Purpose of the Study:

• To identify and summarize existing research on interventions for managing cognitive fatigue in multiple sclerosis.
• To provide a comprehensive overview of current treatment options for MS-related cognitive fatigue.

Main Methods:

• A systematic scoping review was conducted using the PRISMA Extension methodology.
• Searches were performed across multiple databases (CINAHL, MEDLINE, PsycINFO, Embase, ProQuest) in May 2021.
• Peer-reviewed articles in English or French focusing on interventions for MS cognitive fatigue were included and analyzed.

Main Results:

• Thirty-four studies were included, primarily involving middle-aged adults with relapsing-remitting MS.
• Interventions were categorized into educational programs (18 studies), medical/pharmacological (6 studies), and exercise/physical (10 studies).
• Fatigue self-management programs incorporating educational materials and facilitators appeared most effective for reducing cognitive fatigue.

Conclusions:

• A range of interventions for managing cognitive fatigue in MS has been identified.
• Current evidence is insufficient to provide definitive recommendations for effective cognitive fatigue management strategies.
• Further research is crucial to establish clear and evidence-based approaches for MS cognitive fatigue.