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Published on: August 15, 2022
Recommendations for Donor and Recipient Selection and Risk Prediction: Working Group Report From the ILTS Consensus
Andrea Schlegel1,2, David P Foley3, Eric Savier4
1The Liver Unit, Queen Elizabeth Hospital Birmingham, Edgbaston, Birmingham, United Kingdom.
Insights
Guidelines for liver transplantation using donation after circulatory death donors (DCDs) were developed. Experts addressed donor and recipient risk factors and prediction models for DCD liver transplants (DCD-LT).
Area of Science:
- Hepatology
- Transplantation Surgery
- Organ Donation
Background:
- Donation after circulatory death donors (DCDs) are increasingly used for liver transplantation (LT).
- Current clinical practice lacks universally accepted criteria for DCD donor and recipient risk factors and prediction models.
- This highlights a need for standardized guidelines in DCD liver transplantation (DCD-LT).
Framework:
- A consensus conference by the International Liver Transplantation Society convened experts on January 31, 2020, in Venice, Italy.
- The conference utilized a grade system to review global DCD-LT practices.
- International experts formed 6 working groups to develop evidence-based recommendations.
Implementation:
- Working groups addressed specific questions on donor and recipient risk factors and prediction models in DCD-LT.
- Recommendations were based on a thorough review of existing scientific literature.
- Conference attendees and working group members acted as a jury to finalize these recommendations.
Implications:
- The report presents consensus-based statements and guidelines for DCD-LT.
- These recommendations aim to standardize the use of DCD donors in liver transplantation.
- The findings will guide clinical practice regarding donor and recipient selection and risk assessment in DCD-LT.
Abstract:
Although the utilization of donation after circulatory death donors (DCDs) for liver transplantation (LT) has increased steadily, much controversy remains, and no common acceptance criteria exist with regard to donor and recipient risk factors and prediction models. A consensus conference was organized by International Liver Transplantation Society on January 31, 2020, in Venice, Italy, to review the current clinical practice worldwide regarding DCD-LT and to develop internationally accepted guidelines. The format of the conference was based on the grade system. International experts in this field were allocated to 6 working groups and prepared evidence-based recommendations to answer-specific questions considering the currently available literature. Working group members and conference attendees served as jury to edit and confirm the final recommendations presented at the end of the conference by each working group separately. This report presents the final statements and recommendations provided by working group 2, covering the entire spectrum of donor and recipient risk factors and prediction models in DCD-LT.
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