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Published on: August 8, 2022
[Cirrhotic cardiomyopathy]
Insights
Cirrhotic cardiomyopathy (CCM) involves heart dysfunction in advanced liver disease, often hidden until stress. Early cardiac evaluation is key for managing risks in these patients.
Area of Science:
- Cardiology
- Hepatology
- Internal Medicine
Background:
- Cirrhotic cardiomyopathy (CCM) is a cardiac dysfunction in end-stage liver disease.
- It presents as systolic and/or diastolic dysfunction without prior heart conditions.
- Cardiac issues are often unapparent at rest but emerge during physiological stress.
Purpose of the Study:
- To review the characteristics and diagnostic challenges of cirrhotic cardiomyopathy.
- To highlight the importance of cardiac evaluation in patients with liver disease.
Main Methods:
- Diagnosis relies on echocardiography to detect subclinical cardiac dysfunction.
- Additional criteria include electrophysiological abnormalities (e.g., QT prolongation).
- Biomarkers (natriuretic peptides) and structural changes (left atrium enlargement) are also considered.
Main Results:
- CCM is characterized by impaired cardiac function, particularly under stress.
- Diagnosis requires a combination of imaging, electrophysiological, and biomarker assessments.
- No specific treatment exists for CCM.
Conclusions:
- Management focuses on supportive care and regular cardiac monitoring for high-risk individuals.
- Cardiac evaluation is crucial for transplant candidates and patients undergoing invasive procedures.
- Proactive management can mitigate risks associated with CCM in liver disease patients.
Abstract:
A cirrhotic cardiomyopathy (CCM) can be observed in patients with end-stage liver disease and is characterized by a systolic and/or diastolic dysfunction in the absence of pre-existing heart diseases. While the cardiac dysfunction is often masked at rest, it typically manifests itself during cardiovascular challenges such as hypovolemia, physical stress, or sepsis. The diagnosis of CCM is challenging and predominantly based on echocardiographic measurements to identify subclinical cardiac dysfunction. Additional diagnostic criteria include electrophysiological abnormalities such as QT-interval prolongation, an abnormal chronotropic or inotropic response to stress, elevated cardiac biomarkers such as natriuretic peptides, and structural cardiac abnormalities like left atrium enlargement. There is no specific therapy for CCM. Supportive measures and regular cardiac evaluation of high-risk patients and transplant candidates are important to reduce the risks associated with invasive procedures and treatments.
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