Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

3.5K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
3.5K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

2.2K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
2.2K
Glucose Transporters01:27

Glucose Transporters

26.2K
Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
26.2K
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

3.9K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
3.9K
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

35.7K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
35.7K
Inborn Errors of Metabolism01:20

Inborn Errors of Metabolism

355
Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
355

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Inhibition of ferroptosis improves developmental competence of vitrified-warmed oocytes.

Frontiers in endocrinology·2026
Same author

Association of maternal hemoglobin levels and chorioamnionitis with preterm birth and low birth weight: a cohort study.

World journal of pediatrics : WJP·2026
Same author

Charting human organogenesis across the Carnegie stages from a whole-embryo perspective.

GigaScience·2026
Same author

Spatiotemporal transcriptome atlas of human embryos after gastrulation.

Nature·2026
Same author

Cell-free DNA fragmentomics for preeclampsia risk assessment.

Nature communications·2026
Same author

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Related Experiment Video

Updated: Oct 23, 2025

Author Spotlight: Exploring the Long-Term Health Impacts of Intracytoplasmic Sperm Injection on Offspring
06:11

Author Spotlight: Exploring the Long-Term Health Impacts of Intracytoplasmic Sperm Injection on Offspring

Published on: May 17, 2024

829

Intrauterine hyperglycemia impairs memory across two generations.

Kexin Zou1,2,3, Jun Ren4, Sisi Luo1,2,3

  • 1The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Translational Psychiatry
|August 21, 2021
PubMed
Summary

Gestational diabetes mellitus (GDM) during pregnancy can impair offspring memory. This study reveals altered sperm methylation in male offspring, suggesting an epigenetic mechanism for these neurocognitive effects.

More Related Videos

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory
10:03

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory

Published on: February 28, 2013

26.1K
Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid
06:21

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid

Published on: April 7, 2023

1.8K

Related Experiment Videos

Last Updated: Oct 23, 2025

Author Spotlight: Exploring the Long-Term Health Impacts of Intracytoplasmic Sperm Injection on Offspring
06:11

Author Spotlight: Exploring the Long-Term Health Impacts of Intracytoplasmic Sperm Injection on Offspring

Published on: May 17, 2024

829
A Zebrafish Model of Diabetes Mellitus and Metabolic Memory
10:03

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory

Published on: February 28, 2013

26.1K
Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid
06:21

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid

Published on: April 7, 2023

1.8K

Area of Science:

  • Neuroscience
  • Endocrinology
  • Epigenetics

Background:

  • Gestational diabetes mellitus (GDM) is linked to neurological issues in offspring.
  • The molecular pathways for these intergenerational effects are not fully understood.

Purpose of the Study:

  • To investigate the intergenerational neurocognitive effects of intrauterine hyperglycemia exposure in a mouse model.
  • To explore the underlying molecular and epigenetic mechanisms.

Main Methods:

  • A mouse model of diabetes during pregnancy was utilized.
  • Transcriptome profiling of hippocampi from first filial (F1) and second filial (F2) offspring was performed.
  • Reduced representation bisulfite sequencing (RRBS) of sperm from F1 males was conducted.

Main Results:

  • Intrauterine hyperglycemia exposure led to memory impairment in F1 and F2 male offspring.
  • Gene expression analysis revealed enrichment of neurodevelopment and synaptic plasticity pathways.
  • Altered DNA methylation patterns were observed in the sperm of exposed F1 males.

Conclusions:

  • Intrauterine hyperglycemia during pregnancy can cause lasting neurocognitive deficits in male offspring across generations.
  • Epigenetic modifications, specifically altered sperm methylation, represent a potential mechanism for these transgenerational effects of GDM.