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Published on: July 4, 2021
Cerebral venous sinus thrombosis in patients with inflammatory bowel disease: a retrospective study
Wang Shujun1, Zhang Huijie1, Bai Xia1
1Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe East Road, Zhengzhou, 450052, People's Republic of China.
Insights
Cerebral venous sinus thrombosis (CVST) is a rare complication in inflammatory bowel disease (IBD) patients. Early detection of risk factors like anemia and elevated D-dimer, followed by prompt anticoagulation, improves outcomes.
Area of Science:
- Gastroenterology
- Neurology
- Hematology
Background:
- Cerebral venous sinus thrombosis (CVST) is a rare but serious complication of inflammatory bowel disease (IBD).
- Early diagnosis and prompt treatment are crucial for improving patient prognosis in IBD-associated CVST.
Purpose of the Study:
- To investigate the clinical data and predictive factors of CVST in patients with IBD.
- To compare clinical data, predictive factors, and prognosis between IBD patients with and without CVST.
Main Methods:
- Retrospective analysis of IBD patient data collected between July 2013 and September 2020.
- Comparison of clinical characteristics, risk factors, and outcomes between IBD patients with CVST and a control group.
Main Results:
- The incidence of CVST in the IBD cohort was 0.48%.
- Common symptoms included headache (73.1%) and vomiting (30.8%). The transverse sinus was the most frequently affected location (61.5%).
- Anemia, low albumin, and elevated D-dimer were identified as independent predictors of CVST in IBD patients. Anticoagulation therapy was effective, but prognosis was poorer compared to IBD patients without CVST.
Conclusions:
- Early identification of CVST risk factors and clinical features in IBD patients is essential.
- Prompt antithrombotic therapy is a safe and effective treatment strategy for IBD-associated CVST.
Abstract:
Cerebral venous sinus thrombosis (CVST) is a rare and devastating complication of inflammatory bowel disease (IBD). Early diagnosis and prompt treatment could improve prognosis. The aim of our study was to investigate the clinical data and predictive factors of inflammatory bowel disease in patients with a diagnosis of CVST. All IBD patient data were collected from July 2013 and September 2020. Clinical data, predictive factors and prognosis were compared between IBD patients with CVST and the IBD control group. The incidence of CVST in our study was 0.48%. The mean age of IBD patients with CVST was 34.9 years. The average duration of IBD was 4 years when cerebrovascular events occurred. The clinical presentation of CVST included headache (73.1%), vomiting (30.8%), limb dysmetria (26.9%), speech impairment (11.5%), blurred vision (7.7%), epileptic seizures (7.7%) and drowsiness (3.8%). The most common location for CVST was the transverse sinus (61.5%) followed by the superior sagittal sinus (30.8%). Anaemia, low albumin and elevated D-dimer were independent predictors of CVST in patients with IBD. Anticoagulation therapy was effective. The prognosis of IBD patients with CVST was worse than that of IBD patients without CVST. Early identification of the risk and clinical features of CVST in IBD patients is important. Prompt antithrombotic therapy is a safe and effective treatment.
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