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Updated: Oct 23, 2025

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
Published on: February 6, 2020
Aminoesterenamide Achieved by Three-Component Reaction Heading toward Tailoring Covalent Adaptable Network with Great
Youwei Ma1, Zhiyong Liu2, Shuai Zhou1
1School of Chemistry and Chemical Engineering, State Key Laboratory for Metal Matrix Composite Materials, Shanghai Key Lab of Electrical Insulation & Thermal Ageing, Shanghai Jiao Tong University, Shanghai, 200240, P. R. China.
Abstract:
Covalent adaptable networks (CANs) have recently received extensive interests due to their reprocessability and repairability. Rethinking the libraries of the published CANs, most of them are fabricated by one/two-component reactions and few cases utilize multi-component reactions to construct CANs while multi-component reactions are conductive to tailoring the properties of polymers due to their structural designability and flexible choice of raw materials. A novel kind of dynamic covalent bond named aminoesterenamide is presented through three-component reaction between acetoacetyl, amine and isocyanate. Aminoesterenamide exhibits thermal reversibility through dissociating into vinylogous urethane and isocyanate. When it is used to prepare CANs, the synthesized polymer networks can be reprocessed many times via the exchange reaction between aminoesterenamides. Moreover, the forming of aminoesterenamide involving three starting components imparts CANs with great freedom to tailor their properties. Therefore, the authors believe this method that utilizes three-component reaction to fabricate CANs would bring new stories and perspectives to the exploration of new types of CANs.
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