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Three new alkaloids from Portulaca oleracea L. and their bioactivities
Xinyu Cui1, Zheming Ying2, Xixiang Ying1
1School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, Liaoning, PR China.
Abstract:
Three novel alkaloids, named oleracone L (1), portulacatone B (2), and portulacatal (3), were isolated from P. oleracea L.. The structures were determined using UV, IR, 1D and 2D NMR spectroscopy and UHPLC-ESI-QTOF/MS. The three compounds in a dose-dependent manner significantly reduced the secretion of IL-1β in the lipopolysaccharide-stimulated macrophages RAW 264.7 cell culture supernatant, moreover, exhibited the anticholinesterase activities.
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