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Updated: Oct 23, 2025

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Organoids in modelling infectious diseases.

Anastasia Shpichka1, Polina Bikmulina2, Maria Peshkova3

  • 1World-Class Research Center 'Digital Biodesign and Personalized Healthcare', Sechenov First Moscow State Medical University, Moscow, Russia; Institute for Regenerative Medicine, Sechenov First Moscow State Medical University, Moscow, Russia; Chemistry Department, Lomonosov Moscow State University, Moscow, Russia.

Drug Discovery Today
|August 21, 2021
PubMed
Summary

Organoids offer a flexible tool for studying viral, bacterial, and protist infections, providing rapid insights for drug screening and combating emerging infectious diseases.

Keywords:
BacteriaDrug screeningInfectionInfectious diseasesOrganoidsProtistsViruses

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Area of Science:

  • Infectious Diseases
  • Biotechnology
  • Pathogen Research

Background:

  • Traditional animal and 2D cell culture models have limitations in reliably modeling novel pathogens and for short-term drug testing.
  • Organoids are emerging as a promising alternative platform for infection modeling due to their complex, three-dimensional structure.

Purpose of the Study:

  • To provide a framework of recent achievements in applying organoids for modeling various infections.
  • To highlight the potential of organoids in overcoming current challenges in infectious disease research and drug development.

Main Methods:

  • Review and synthesis of existing research on organoid applications in studying viral, bacterial, and protist infections.
  • Analysis of organoid capabilities in modeling different disease types (respiratory, gastrointestinal, liver).

Main Results:

  • Organoids have been successfully employed to study a range of pathogens causing diverse diseases.
  • Current organoid models provide fast and reliable information crucial for understanding pathogen biology and for drug screening.

Conclusions:

  • Organoids represent a flexible and essential tool for modeling infectious diseases, aiding in the fight against emerging threats.
  • Future advancements in organoid complexity, including tissue structure and microenvironment modeling, will further enhance their utility.