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Updated: Oct 23, 2025

Multifocal Electroretinograms

Multifocal Electroretinograms

Published on: December 4, 2011

Relationship between structural and functional changes in glaucomatous eyes: a multifocal electroretinogram study.

Hiroki Tanaka¹, Kyoko Ishida², Kenji Ozawa¹

¹Department of Ophthalmology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu-shi, Gifu, 501-1194, Japan.

BMC Ophthalmology

|August 22, 2021

Summary

The nasal to temporal amplitudes ratio (N/T) of multifocal electroretinography (mfERG) shows stronger correlations with optical coherence tomography (OCT) and visual field (VF) parameters in glaucoma detection than the photopic negative response to B-wave ratio (PhNR/B). Further research is needed to optimize mfERG for clinical use.

Keywords:

Humphrey field analyzer Multifocal electroretinography Open angle glaucoma Optical coherence tomography

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Area of Science:

Ophthalmology
Neuroscience

Background:

The nasal to temporal amplitudes ratio (N/T) of multifocal electroretinography (mfERG) and the photopic negative response to B-wave ratio (PhNR/B) are potential indicators for detecting glaucomatous changes.
While both parameters show promise, their clinical superiority in evaluating glaucoma patients remains undetermined.

Purpose of the Study:

To compare the diagnostic efficacy of N/T and PhNR/B parameters derived from mfERG in glaucoma assessment.
To evaluate the correlations between mfERG parameters and morphological (OCT) and functional (VF) assessments in glaucoma patients.

Main Methods:

Sixty-nine eyes from 44 glaucoma patients underwent morphological assessment using optical coherence tomography (OCT) for ganglion cell complex (GCC) thickness.
Functional assessment included Humphrey visual fields (VF) and mfERG measurements for N/T and mfPhNR/B parameters.
Correlations between mfERG parameters and OCT or VF measurements were analyzed.

Main Results:

The N/T parameter demonstrated significant correlations with GCC thickness and VF parameters, particularly in the inferior and inforotemporal retinal areas.
Conversely, the mfPhNR/B parameter showed limited association with OCT and VF parameters, with a significant correlation only found in the inferotemporal sector with GCC thickness.
These findings suggest N/T may be more sensitive in detecting glaucomatous changes across multiple retinal areas compared to mfPhNR/B.

Conclusions:

The N/T parameter exhibited a broader correlation with GCC and VF measurements than mfPhNR/B in this study.
Future research should focus on refining mfERG stimuli and amplitudes to enhance spatial correspondence with OCT and VF for improved clinical evaluation of glaucoma.