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Serum levels of Asprosin in patients diagnosed with coronary artery disease (CAD): a case-control study

Nariman Moradi1, Fatima Zahraa Fouani2, Akram Vatannejad3

  • 1Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.

Lipids in Health and Disease
|August 22, 2021
PubMed

Insights

Elevated serum asprosin levels are linked to coronary artery disease (CAD) development. This fasting-induced adipokine may contribute to CAD pathogenesis, particularly through insulin resistance and dyslipidemia.

Area of Science:

  • Cardiovascular Research
  • Endocrinology
  • Metabolic Syndrome

Background:

  • Coronary artery disease (CAD) is a chronic inflammatory condition linked to visceral adiposity and disrupted adipokine release.
  • Asprosin, a novel fasting-induced adipokine, is associated with metabolic disorders like type II diabetes mellitus and polycystic ovary syndrome.

Purpose of the Study:

  • To investigate the association between circulating asprosin levels and the presence of coronary artery disease (CAD).
  • To explore the potential role of asprosin in CAD pathogenesis, considering its links to metabolic factors.

Main Methods:

  • Serum asprosin, IL-6, TNF-α, and adiponectin levels were measured using ELISA kits.
  • The study included 88 patients with CAD and 88 healthy non-CAD controls.
  • Logistic regression analysis was performed to assess the association between asprosin and CAD risk, adjusting for confounders.

Main Results:

  • Serum asprosin levels were significantly higher in CAD patients compared to controls (7.84 ± 2.08 vs. 5.02 ± 1.29 μg/mL, p < 0.001).
  • CAD patients exhibited elevated TNF-α and IL-6, and reduced adiponectin levels.
  • Asprosin levels correlated positively with BMI, fasting blood glucose (FBG), HOMA-IR, triglycerides (TG), and total cholesterol (TC).
  • Asprosin was independently associated with an increased risk of developing CAD (OR: 3.01, 95% CI: 2.16–4.20, p < 0.001).

Conclusions:

  • Circulating asprosin may play a role in the pathogenesis of coronary artery disease.
  • The findings suggest that asprosin's contribution to CAD may be mediated by insulin resistance and dyslipidemia.
Abstract

Keywords:
AdipokineAsprosinCoronary artery diseaseDyslipidemiaInsulin resistance

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