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MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues
Published on: November 30, 2013
MicroRNAs in organ fibrosis: From molecular mechanisms to potential therapeutic targets
Hui Zhao1, Ya-Long Feng2, Tian Liu1
1Clinical Experimental Center, Xi'an International Medical Center Hospital, No. 777 Xitai Road Xi'an, Shaanxi 710100, China; Xi'an Engineering Technology Research Center for Cardiovascular Active Peptids, No. 777 Xitai Road Xi'an, Shaanxi 710100, China.
Abstract:
Fibrosis is caused by chronic tissue injury and characterized by the excessive deposition of extracellular matrix (ECM) that ultimately results in organ failure and death. Owing to lacking of effective treatment against tissue fibrosis, it causes a high morbidity and mortality worldwide. Thus, it is of great importance to find an effective therapy strategy for the treatment of fibrosis. MicroRNAs (miRNAs) play vital roles in many biological processes by targeting downstream genes. Numerous studies demonstrated that miRNAs served as biomarkers of various diseases, suggesting the potential therapeutic targets for diseases. It was recently reported that miRNAs played an important role in the development of organ fibrosis, which showed a promising prospect against fibrosis by targeting intervention. Here, we summarize the roles of miRNAs in the process of organ fibrosis, including liver, lung, heart and kidney, and highlight miRNAs being novel therapeutic targets for organ fibrosis.
Insights
MicroRNAs (miRNAs) show promise in treating organ fibrosis, a condition causing excessive matrix deposition and organ failure. Targeting these microRNAs offers a new therapeutic strategy for fibrosis.
Area of Science:
- Biochemistry
- Molecular Biology
- Pathology
Background:
- Fibrosis, characterized by excessive extracellular matrix deposition, results from chronic tissue injury and leads to organ failure.
- Current treatments for fibrosis are limited, contributing to high global morbidity and mortality.
- MicroRNAs (miRNAs) are crucial regulators of biological processes and emerging biomarkers for diseases.
Purpose of the Study:
- To summarize the roles of microRNAs in the development of organ fibrosis.
- To highlight microRNAs as potential therapeutic targets for treating fibrosis in organs like the liver, lung, heart, and kidney.
Main Methods:
- Literature review of studies investigating microRNA involvement in organ fibrosis.
- Analysis of microRNA functions in the pathogenesis of liver, lung, heart, and kidney fibrosis.
- Identification of specific microRNAs with therapeutic potential.
Main Results:
- MicroRNAs play significant roles in the complex processes underlying organ fibrosis.
- Dysregulation of specific miRNAs is implicated in the progression of fibrosis across multiple organs.
- Targeting these miRNAs presents a promising therapeutic avenue.
Conclusions:
- MicroRNAs are key players in organ fibrosis development.
- MicroRNAs represent novel and promising therapeutic targets for combating fibrosis.
- Further research into miRNA-based therapies could lead to effective treatments for fibrotic diseases.
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