Related Experiment Video

Updated: Oct 23, 2025

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
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Importance of bone turnover for therapeutic decisions in patients with CKD-MBD

Susan M Ott1, Hartmut H Malluche2, Vanda Jorgetti3

  • 1Department of Medicine, University of Washington, Seattle, Washington, USA.

Kidney International
|August 23, 2021
PubMed

Insights

Patients with chronic kidney disease-mineral and bone disorder (CKD-MBD) often have low bone formation. Antiresorptive medications may not improve fracture risk in these patients and could potentially be harmful.

Area of Science:

  • Nephrology
  • Endocrinology
  • Bone Metabolism

Background:

  • Chronic kidney disease-mineral and bone disorder (CKD-MBD) commonly presents with low bone formation rates.
  • Adynamic bone disease, a subtype of low bone turnover, has been suggested to have neutral outcomes in some cases.
  • This has led to consideration of increased use of antiresorptive medications in CKD-MBD.

Purpose of the Study:

  • To evaluate the evidence for the efficacy and safety of antiresorptive medications in patients with CKD-MBD and low bone turnover.
  • To assess the impact of these medications on fracture risk and mortality in this specific patient population.

Main Methods:

  • Review of existing literature and pathophysiological evidence.
  • Analysis of studies investigating antiresorptive treatment in CKD-MBD patients with low bone turnover.

Main Results:

  • Currently, no evidence supports improved fracture risk or mortality with antiresorptive medication in CKD-MBD patients with low bone turnover.
  • Pathophysiological evidence suggests potential harm from antiresorptive agents in this context.

Conclusions:

  • Antiresorptive medications should be used with caution in CKD-MBD patients exhibiting low bone turnover.
  • Further research is needed to clarify the risks and benefits of these treatments in this population.

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