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Updated: Oct 23, 2025

A Modified Precipitation Method to Isolate Urinary Exosomes
Published on: January 16, 2015
EXPLORing exosomes for the treatment of acute kidney injury
Eibhlin Goggins1, Shinji Tanaka1
1Division of Nephrology and Center for Immunity, Inflammation, and Regenerative Medicine, University of Virginia, Charlottesville, Virginia, USA.
Abstract:
Exosomes are emerging as a novel drug delivery system for the treatment of numerous diseases, including acute kidney injury. In this issue of Kidney International, Kim et al. use a novel optogenetically engineered exosome technology, "EXPLOR," to deliver the exosomal repressor of nuclear factor-κB into mice before and after renal ischemia-reperfusion. They report that these exosomes downregulated renal nuclear factor-κB signaling and ameliorated acute kidney injury. This study deserves attention for its significant scientific and potential clinical value in acute kidney injury.
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