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The primary cilium, made up of microtubules, acts as antennae on the cell surfaces for relaying external stimuli into the cells. These fine hair-like structures are present, generally one per cell. These are non-motile cilia in a 9+0 microtubules arrangement, where the central pair of microtubules are absent. The primary cilia arise from the basal body embedded in the cell membrane. Intraflagellar transport (IFT) carries requisite proteins from the cytoplasm to the cilium because the primary...
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Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
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Simple Detection of Primary Cilia by Immunofluorescence
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Primary ciliary signaling: links with the cell cycle.

Kousuke Kasahara1, Masaki Inagaki1

  • 1Department of Physiology, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie 514-8507, Japan.

Trends in Cell Biology
|August 23, 2021
PubMed
Summary

Primary cilia dynamics are controlled by growth factor signaling pathways, impacting cell cycle progression. Understanding this interplay is crucial for cell biology research.

Keywords:
centrosomelipid raftlysophosphatidic acidprimary ciliumreceptor tyrosine kinase

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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Primary cilia are microtubule-based cell structures crucial for signaling.
  • The relationship between primary cilia and the cell cycle is complex and not fully understood.

Purpose of the Study:

  • To review recent advances in the interplay between primary cilia and cell cycle progression.
  • To focus on the role of growth factor signaling pathways in this interaction.

Main Methods:

  • Literature review of recent studies.
  • Analysis of signaling pathways involving receptor tyrosine kinases and lysophosphatidic acid receptors.

Main Results:

  • Growth factor signaling pathways, including those from receptor tyrosine kinases, regulate primary cilia dynamics.
  • Primary cilia act as signaling hubs and influence membrane composition, affecting cellular responses.

Conclusions:

  • Primary cilia assembly and disassembly are linked to cell cycle progression.
  • Understanding the interplay between primary cilia and growth factor signaling is key to resolving mechanistic details.