Related Experiment Videos
[Intestinal scleroderma: clinical aspects, diagnostic possibilities and therapy]
1Hautklinik und Poliklinik, Universität Bonn.
Zeitschrift Fur Hautkrankheiten
|January 1, 1987
Summary
Progressive Systemic Scleroderma (PSS) can affect the intestines, causing symptoms due to bacterial bile acid deconjugation. Treatment involves antibiotics like Tetracycline or Metronidazole, with elevated bile acids indicating diagnosis.
Area of Science:
- Gastroenterology
- Rheumatology
- Immunology
Context:
- Progressive Systemic Scleroderma (PSS) is a systemic connective tissue disease.
- Intestinal manifestations of PSS are uncommon but clinically significant.
- Esophageal involvement is a key factor in gastrointestinal symptoms.
Purpose:
- To explore the pathogenetic relevance of bacterial bile acid deconjugation in intestinal scleroderma.
- To highlight the diagnostic utility of unconjugated serum bile acids.
- To suggest therapeutic interventions for intestinal PSS.
Summary:
- Bacterial deconjugation of bile acids contributes to intestinal symptomatology in PSS.
- Elevated unconjugated serum bile acids (cholic acid, chenodeoxycholic acid) serve as diagnostic markers.
- Parenteral administration of Tetracycline or Metronidazole is a potential treatment approach.
Impact:
- Provides insight into the mechanisms of intestinal PSS.
- Establishes a diagnostic approach using serum bile acid analysis.
- Suggests targeted antibiotic therapy for managing gastrointestinal complications in PSS.