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Related Concept Videos

Atherosclerosis I: Introduction01:30

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Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
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Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

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Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
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Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
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Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
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Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
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Crosstalk between Iron and Arteriosclerosis.

Yoshiro Naito1, Takeshi Tsujino1,2, Tohru Masuyama1,3

  • 1Department of Cardiovascular and Renal Medicine, Hyogo College of Medicine.

Journal of Atherosclerosis and Thrombosis
|August 23, 2021
PubMed
Summary

Iron overload causes cellular damage and is linked to cardiovascular diseases. This review examines the complex role of iron metabolism in arteriosclerosis pathogenesis.

Keywords:
ArteriosclerosisAtherosclerosisIronTransferrin receptor 1

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Area of Science:

  • Biochemistry
  • Cardiovascular Science
  • Cell Biology

Background:

  • Iron is essential for cellular functions like growth and repair.
  • Intracellular iron overload can cause oxidative stress and cellular damage.
  • Body iron status is implicated in cardiovascular disease pathogenesis, including arteriosclerosis.

Purpose of the Study:

  • To review and examine the role of iron in the pathogenesis of arteriosclerosis.
  • To explore the complex relationship between iron metabolism and arteriosclerosis.
  • To elucidate the unsolved systemic and cellular mechanisms of iron homeostasis in arteriosclerosis.

Main Methods:

  • Literature review of clinical and experimental studies.
  • Analysis of existing data on iron-cardiovascular disease associations.
  • Synthesis of information on iron metabolism and cellular damage.

Main Results:

  • Clinical and experimental studies demonstrate an association between iron and arteriosclerosis.
  • Iron's involvement in cellular processes suggests a role in arteriosclerosis pathogenesis.
  • The intricate mechanisms of iron metabolism in arteriosclerosis are not fully understood.

Conclusions:

  • Iron plays a significant role in the pathogenesis of arteriosclerosis.
  • Further research is needed to fully understand iron homeostasis mechanisms in arteriosclerosis.
  • Investigating iron's role may offer new insights into cardiovascular disease treatment.