Related Experiment Video

Updated: Oct 23, 2025

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia
08:05

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia

Published on: December 19, 2020

14.4K

Pathological Features in 100 Deceased Patients With COVID-19 in Correlation With Clinical and Laboratory Data

L M Mikhaleva1, A L Cherniaev1, M V Samsonova1

  • 1Research Institute of Human Morphology, Moscow, Russia.

Pathology Oncology Research : POR
|August 23, 2021
PubMed

Insights

Autopsies reveal widespread coagulopathy and diffuse alveolar damage as key factors in COVID-19 mortality. Extrapulmonary effects on the liver and spleen are also significant in understanding fatal outcomes from SARS-CoV-2 infection.

Area of Science:

  • Pathology
  • Infectious Diseases
  • Forensic Medicine

Background:

  • COVID-19 autopsies face limitations due to safety measures.
  • Clinical data may not align with post-mortem findings.
  • Understanding COVID-19 mortality mechanisms is crucial.

Purpose of the Study:

  • Identify pathognomonic factors in COVID-19 mortality.
  • Correlate clinical and autopsy findings.
  • Analyze 100 full-body autopsies of COVID-19 deceased patients.

Main Methods:

  • Conducted 100 full-body autopsies following safety protocols.
  • Evaluated macroscopic and microscopic pathologies.
  • Assessed clinical and laboratory findings.

Main Results:

  • Widespread coagulopathic changes observed.
  • Diffuse alveolar damage is pathognomonic for COVID-19 pneumonia, especially in younger patients.
  • Extrapulmonary pathology affects liver and spleen; intravascular thrombosis and septic shock are common.

Conclusions:

  • Pathological findings offer insight into SARS-CoV-2 lethality.
  • COVID-19 severity may be influenced by genetic or epigenetic factors.
  • No obvious bias in severity, but individual variability exists.

Keywords:
COVID-19histological subtypelarge cohortmorphologypathological features

More Related Videos

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans08:29

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans

Published on: December 18, 2016

14.2K
Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses03:53

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses

Published on: November 10, 2023

1.5K

Related Concept Videos

COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
741
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
52
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

The pathophysiology of pneumonia involves the following steps:
1.1K
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
49
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
85
Pericarditis II: Clinical Features and Diagnostic Tests01:19

Pericarditis II: Clinical Features and Diagnostic Tests

Pericarditis is distinguished by inflammation of the pericardium, the fibrous sac that encases the heart. It can be acute, lasting less than six weeks, or chronic, persisting for over three months. Understanding its clinical manifestations and diagnostic findings is crucial for timely and effective management.Clinical ManifestationsWhile pericarditis can be asymptomatic, it usually presents with characteristic symptoms such as:Chest Pain: The most characteristic symptom of pericarditis is chest...
70