Related Experiment Video
Updated: Oct 23, 2025
11:09
High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals
Published on: December 16, 2022
4.0K
Incidental Detection of Ischemic Myocardium on 68 Ga-FAPI PET/CT
Piyush Chandra1, Satish Nath1, Jaishankar Krishnamoorthy2
1Department of Nuclear, Medicine, MIOT International, Chennai, India.
Nuclear Medicine and Molecular Imaging
|August 23, 2021
Summary
Gallium-68 fibroblast activation protein inhibitor (FAPI) PET scans can reveal coronary artery disease. This case highlights incidental FAPI uptake in the heart, correlating with myocardial ischemia and coronary stenosis.
Area of Science:
- Nuclear Medicine
- Cardiology
- Oncology
Background:
- Ga-68 labeled fibroblast activation protein inhibitors (FAPI) PET imaging is increasingly used.
- Studies suggest FAPI uptake in the myocardium correlates with coronary artery disease (CAD).
Purpose of the Study:
- To present a case of incidental FAPI PET uptake in the left ventricle myocardium.
- To correlate this finding with ischemia and coronary stenosis.
Main Methods:
- A 76-year-old female patient with breast cancer underwent Ga-68 FAPI PET.
- Findings were correlated with dobutamine stress myocardial perfusion imaging (MPI) and coronary angiography.
Main Results:
- Incidental focal FAPI uptake was observed in the apex and septal wall of the left ventricle.
- This uptake corresponded to areas of ischemia on MPI and anatomical stenosis on coronary angiography.
Conclusions:
- Ga-68 FAPI PET may reveal cardiac abnormalities like ischemia.
- FAPI PET could potentially serve as a non-invasive tool for detecting CAD in specific patient populations.
More Related Videos
![Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography FDG-PET/CT](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F3777.jpg&w=3840&q=50)
Related Concept Videos
01:13Radiological Investigation III: Pulmonary Angiogram and PET Scan
199
Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
199
01:28Imaging Studies for Cardiovascular System V: CT
102
Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
102
01:29Positron Emission Tomography
6.3K
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
6.3K