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Case Report: Mitral Valve Involvement and First-Degree Atrial-Ventricular Block in Two Patients With Multisystem

Paola Di Filippo1, Massimiliano Raso1, Marta Cacciatore1

  • 1Department of Pediatrics, University of Chieti, Chieti, Italy.

Frontiers in Pediatrics
|August 23, 2021
PubMed

Insights

Multisystem Inflammatory Syndrome in Children (MIS-C) is a rare but serious condition following COVID-19. Early treatment with immunoglobulin and steroids shows good outcomes in pediatric patients.

Area of Science:

  • Pediatric infectious diseases
  • Pediatric critical care medicine
  • Immunology

Background:

  • COVID-19 is generally less severe in children than adults.
  • A hyperinflammatory syndrome, Multisystem Inflammatory Syndrome in Children (MIS-C), emerged in children post-COVID-19.
  • MIS-C presents with fever, multiorgan involvement, and requires urgent medical attention.

Observation:

  • Two pediatric cases of MIS-C are presented.
  • Symptoms included fever, rash, and mild cardiac involvement (mitral valve and AV block).
  • Cases followed a paucisymptomatic COVID-19 infection.

Findings:

  • Prompt treatment with intravenous immunoglobulin, oral aspirin, and intravenous corticosteroids led to positive outcomes.
  • The described cardiac involvement was transient and mild.
  • The study highlights effective acute management strategies.

Implications:

  • Further research is crucial to understand MIS-C pathogenesis and long-term effects.
  • Standardized treatment protocols and therapy tapering guidelines for MIS-C are needed.
  • Early recognition and management are key for favorable outcomes in pediatric MIS-C.

Keywords:
COVID-19MIS-C multisystem inflammatory syndrome in childrenSARS–CoV−2childheart involvement

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