Related Experiment Video

Updated: Oct 23, 2025

Studying RNA Interactors of Protein Kinase RNA-Activated during the Mammalian Cell Cycle
10:05

Studying RNA Interactors of Protein Kinase RNA-Activated during the Mammalian Cell Cycle

Published on: March 5, 2019

6.6K

Regulatory Non-coding RNAs for Death Associated Protein Kinase Family

Qingshui Wang1,2, Youyu Lin2, Wenting Zhong2

  • 1Central Laboratory at the Second Affiliated Hospital of Fujian Traditional Chinese Medical University, Collaborative Innovation Center for Rehabilitation Technology, Fujian University of Traditional Chinese Medicine, Fuzhou, China.

Frontiers in Molecular Biosciences
|August 23, 2021
PubMed

Insights

Death Associated Protein Kinases (DAPKs) regulate apoptosis and tumor development. This review highlights how non-coding RNAs, such as miRNAs, lncRNAs, and circRNAs, influence DAPKs in cancer.

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Biochemistry

Background:

  • Death Associated Protein Kinases (DAPKs) are serine/threonine kinases critical for apoptosis regulation.
  • DAPK family members (DAPK1, DAPK2, DAPK3) are implicated in malignant tumor progression, affecting apoptosis, proliferation, invasion, and metastasis.
  • Non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), are key regulators of gene expression and tumorigenesis.

Purpose of the Study:

  • To review the current understanding of non-coding RNA involvement in regulating DAPKs.
  • To identify specific miRNAs, lncRNAs, and circRNAs that interact with and modulate DAPK family members.
  • To consolidate knowledge on the role of ncRNA-DAPK interactions in cancer development.

Main Methods:

  • Literature review of existing studies on DAPKs and non-coding RNAs in cancer.
  • Analysis of recent research identifying specific ncRNAs targeting DAPK family members.
  • Synthesis of findings on the functional impact of these interactions on cancer hallmarks.

Main Results:

  • Non-coding RNAs have emerged as significant regulators of DAPK family members.
  • Specific miRNAs, lncRNAs, and circRNAs have been identified that target and influence DAPK expression and function.
  • These ncRNA-DAPK interactions play a role in modulating cancer-related processes like apoptosis and cell proliferation.

Conclusions:

  • Non-coding RNAs represent a crucial layer of regulation for DAPKs in the context of cancer.
  • Understanding these ncRNA-DAPK interactions provides potential therapeutic targets for cancer treatment.
  • Further research into specific ncRNA-DAPK pathways is warranted to fully elucidate their roles in tumorigenesis.
Keywords:
DAPKcircRNAlncRNAmiRNAnon-coding RNA

More Related Videos

In Vivo Biosensor Tracks Non-apoptotic Caspase Activity in Drosophila13:21

In Vivo Biosensor Tracks Non-apoptotic Caspase Activity in Drosophila

Published on: November 27, 2016

9.2K
Measuring Caspase Activity Using a Fluorometric Assay or Flow Cytometry05:29

Measuring Caspase Activity Using a Fluorometric Assay or Flow Cytometry

Published on: March 24, 2023

4.9K

Related Concept Videos

Regulation of the Unfolded Protein Response01:31

Regulation of the Unfolded Protein Response

Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...
2.7K
PI3K/mTOR/AKT Signaling Pathway01:22

PI3K/mTOR/AKT Signaling Pathway

The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
4.2K
The Extrinsic Apoptotic Pathway01:17

The Extrinsic Apoptotic Pathway

The extrinsic apoptotic pathway is initiated when extracellular death-inducing signals, such as specific cytokines, activate the death receptors expressed on the cell surface. The immune cells involved in this pathway are natural killer cells (NK cells) and cytotoxic T-lymphocytes. NK cells are critical in innate immune response, while cytotoxic T-lymphocytes are associated with adaptive immune response. These cells recognize specific receptors expressed on the altered cells and activate...
6.8K
The Intrinsic Apoptotic Pathway01:31

The Intrinsic Apoptotic Pathway

Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
7.1K
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
9.6K
MAPK Signaling Cascades01:07

MAPK Signaling Cascades

Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...
6.6K