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A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration
Published on: January 22, 2016
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Executive Function and Contingency Management in Methamphetamine Use Disorder
Lara J van Nunen1, Marilyn T Lake1,2, Jonathan C Ipser1
1Department of Psychiatry and Mental Health, University of Cape Town, Neuroscience Institute, South Africa.
Journal of Alcoholism and Drug Dependence
|August 23, 2021
Summary
Executive function tests at baseline may predict treatment success for individuals with methamphetamine use disorder (MUD). Poorer performance on these tests indicates a lower likelihood of responding to contingency management interventions.
Area of Science:
- Neuroscience
- Psychiatry
- Addiction Medicine
Background:
- Methamphetamine Use Disorder (MUD) poses significant public health challenges.
- Contingency management (CM) shows promise for treating MUD.
- Impaired executive function may hinder treatment adherence and outcomes in MUD.
Purpose of the Study:
- To investigate if baseline executive function predicts treatment response to CM in MUD.
- To assess the utility of executive function tests in identifying individuals likely to benefit from CM.
Main Methods:
- Thirty MUD participants and 23 healthy controls completed the Connors Continuous Performance Task (CPT) and Trail Making Task.
- MUD participants underwent an 8-week CM trial.
- Participants were classified as responders or non-responders based on urine test results.
Main Results:
- MUD participants exhibited poorer performance on the CPT compared to controls.
- Non-responders to CM showed significantly worse performance on the CPT and Trail Making Task B compared to responders.
- While not significantly different from controls, Trail Making Task B performance varied, with non-responders performing worse.
Conclusions:
- Baseline executive function assessments may aid in predicting CM treatment response for MUD.
- These findings support the potential for personalized treatment approaches in MUD based on cognitive function.
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