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Australia and New Zealand Transplant and Cellular Therapies COVID-19 vaccination consensus position statement

Nada Hamad1, Michelle Ananda-Rajah2, Nicole Gilroy3

  • 1St Vincent's Hospital Sydney and University of New South Wales, Sydney, New South Wales, Australia.

Internal Medicine Journal
|August 23, 2021
PubMed

Insights

Patients undergoing bone marrow or cellular therapy (TCT) should receive expedited COVID-19 vaccination due to high risk. Vaccination of TCT healthcare workers and household members is also recommended, with ongoing data collection prioritized.

Area of Science:

  • Hematology
  • Immunology
  • Infectious Diseases

Background:

  • Australia and New Zealand have maintained strong community control of COVID-19.
  • The rollout of COVID-19 vaccines presents a critical juncture for vulnerable patient populations.

Purpose of the Study:

  • To provide a consensus position statement on COVID-19 vaccination for patients undergoing allogeneic and autologous transplant and cellular therapy (TCT) in Australia and New Zealand.
  • To guide clinical practice and policy for TCT patients in the context of widespread vaccination programs.

Main Methods:

  • Collaboration between TCT centers (adult and pediatric, allogeneic and autologous) and infectious disease specialists.
  • Development of a consensus position statement based on expert opinion and risk assessment.

Main Results:

  • Recommended expedited access to high-efficacy COVID-19 vaccines for TCT patients.
  • Recommended prioritization of vaccination for TCT healthcare workers and household contacts.
  • Stressed that vaccination should not replace existing public health measures due to unknown vaccine effectiveness in TCT patients.

Conclusions:

  • TCT patients are at high risk of morbidity and mortality from COVID-19, necessitating prompt vaccination.
  • Ongoing prospective data collection on the safety and efficacy of COVID-19 vaccines in TCT patients is crucial.
  • A multi-faceted approach including patient, healthcare worker, and household vaccination, alongside continued public health measures, is advised.

Keywords:
COVID-19allogeneic stem cell transplantautologous stem cellcellular therapytransplantvaccination

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