Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The limits of ascertainment.

W J Ewens1, N C Shute

  • 1Department of Mathematics, Monash University, Clayton, Victoria, Australia.

Annals of Human Genetics
|October 1, 1986
PubMed
Summary

Ascertainment sampling methods often use incorrect

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Simulating the component counts of combinatorial structures.

Theoretical population biology·2018
Same author

RANDOM SAMPLING AND THE RATE OF GENE REPLACEMENT.

Evolution; international journal of organic evolution·2017
Same author

THE PROBABILITY OF FIXATION OF A MUTANT: THE TWO-LOCUS CASE.

Evolution; international journal of organic evolution·2017
Same author

A genetic model having complex linkage behaviour.

TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·2014
Same author

Locating genes by linkage and association.

Theoretical population biology·2002
Same author

Significance testing for direct identity-by-descent mapping.

Annals of human genetics·2000

Area of Science:

  • Genetics
  • Biostatistics
  • Epidemiology

Background:

  • Ascertainment sampling is crucial in genetic and epidemiological studies for estimating disease prevalence and risk.
  • The 'proband' concept and associated formulas are commonly used in ascertainment sampling.
  • Existing methods may lead to inaccurate estimations due to limitations in the 'limits of ascertainment'.

Purpose of the Study:

  • To identify and discuss the limitations of commonly used 'limits of ascertainment' in genetic and epidemiological studies.
  • To present an alternative estimation procedure that overcomes these limitations.

Main Methods:

  • Analysis of data suggesting sampling schemes that fall outside the traditional 'limits of ascertainment'.
  • Development and evaluation of an estimation procedure that does not rely on the 'proband' concept.

Main Results:

  • The study demonstrates that traditional 'limits of ascertainment' based on the proband concept can be incorrect.
  • Data were presented supporting sampling schemes that deviate from these incorrect limits.
  • The proposed estimation procedure is not constrained by the incorrect limits, offering broader applicability.

Conclusions:

  • The proband concept and associated formulas can lead to significant errors in ascertainment sampling.
  • An alternative estimation method, free from the proband concept, provides more accurate results.
  • Researchers should consider alternative methods to avoid the pitfalls of traditional 'limits of ascertainment'.

Related Experiment Videos