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[Effects of normobaric oxygen on rat hepatocytes]
A Nasraoui1, G Feldman, J J Pocidalo
1Unité N. 13 INSERM Hôpital Claude Bernard, Paris, France.
Archives De L'Institut Pasteur De Tunis
|October 1, 1987
Abstract:
Exposure of adult rats to oxygen (100%) during 55 hrs decreases their sleeping time induced by pentobarbital and doesn't modify their paralysis time provoked by zoxazolamine. At 48 and 55 hrs, the hepatic cytochrome P-450 decreases significantly. Morphological study showed tissular changes suggestive of hepatic hemodynamic perturbations, which are probably responsible for the functional modifications.