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Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA
Published on: December 19, 2019
Case 297
Alexandre Fligelman Kanas1, Sandro Santos Fenelon1, João Manoel Miranda Magalhães Santos1
1From the Department of Radiology and Oncology, Divisions of Interventional Radiology (A.F.K.) and Diagnostic Radiology (S.S.F., J.M.M.M.S., P.C.C.V.), and Department of Surgery, Division of Urology (R.F.C., G.B.G., W.C.N.), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Av. Dr. Enéas Carvalho de Aguiar 255, Cerqueira César, São Paulo, SP 05403-000, Brazil.
Abstract:
History A 70-year-old man was referred to our institution with chronic obstructive urinary symptoms and constipation for 2 years before admission. His medical history was unremarkable. Outside laboratory tests revealed an elevated serum prostate-specific antigen level (21.7 ng/mL [normal range, 0.00-4.00 ng/mL]), and urinalysis results were negative. He was admitted for evaluation of possible prostate cancer. The patient reported no specific symptoms of infection and denied fever, dysuria, hematuria, and abdominal pain. He had no family history of prostate cancer. On physical examination, he was afebrile, and the digital rectal examination was not painful. These findings were evidence of an enlarged prostate and a hard multilobulated mass, which was palpable bilaterally. The urologic team performed MRI of the prostate (Figs 1-4).
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