Related Experiment Video
Updated: Oct 23, 2025
Regenerative Therapy by Suprachoroidal Cell Autograft in Dry Age-related Macular Degeneration: Preliminary In Vivo Report
Published on: February 12, 2018
Plasma rich in growth factors (PRGF -ENDORET®) to rescue necrotized orbital dermis-fat grafts
Ricardo Machado Soares1, Sandra Prazeres Lopes1
1Department of Ophthalmology, Centro Hospitalar de Vila Nova de Gaia e Espinho EPE, Porto, Portugal.
Purpose:
We report on the clinical course of three patients treated with topical plasma rich in growth factors (PRGF) to rescue dermal-fat grafts (DFG) with graft ulceration (GU).
Materials And Methods:
A retrospective, case-series study of three patients diagnosed with GU in DFG and treated with PRGF. Drops were applied four times per day and treatment was maintained until the GU resolved. Data were collected from medical records and anterior segment photos.
Results:
All patients showed a favorable response to topical PRGF having accomplished full resolution of the GU within a mean of 30 days of treatment (range: 21-35 days). During the full extent of follow-up, no side-effects, signs of rejection or necrosis were reported and every patient was pleased with the final aesthetic result.
Conclusion:
Our results suggest that PRGF could be an effective treatment for dermal graft ulceration in patients who underwent DFG surgery/implantation, mainly due to its low morbidity when compared to traditional procedures.
