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Long non-coding RNAs as the critical regulators of doxorubicin resistance in tumor cells

Ghazaleh Khalili-Tanha1, Meysam Moghbeli2

  • 1Department of Medical Genetics and Molecular Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Cellular & Molecular Biology Letters
|August 24, 2021
PubMed

Insights

Long non-coding RNAs (lncRNAs) are key players in doxorubicin (DOX) resistance, often promoting it. Understanding these lncRNAs can help predict patient response to DOX therapy and improve cancer treatment outcomes.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Drug resistance is a major cause of cancer treatment failure and relapse.
  • Doxorubicin (DOX) is a vital chemotherapy drug, but resistance limits its efficacy and causes side effects.
  • Understanding the mechanisms of DOX resistance is crucial for developing better cancer therapies.

Purpose of the Study:

  • To review and summarize the current knowledge on long non-coding RNAs (lncRNAs) involved in doxorubicin resistance.
  • To highlight the role of lncRNAs in promoting or potentially overcoming DOX resistance.
  • To explore the potential of lncRNAs as biomarkers for predicting DOX response.

Main Methods:

  • Literature review of studies investigating lncRNAs and doxorubicin resistance.
  • Analysis of identified lncRNAs' mechanisms in modulating drug resistance.
  • Synthesis of findings to establish the role of lncRNAs in cancer drug resistance.

Main Results:

  • Numerous long non-coding RNAs (lncRNAs) have been identified as regulators of doxorubicin (DOX) resistance in various cancers.
  • The majority of identified lncRNAs promote resistance by influencing pathways like drug efflux, DNA repair, and apoptosis.
  • lncRNAs represent a significant molecular basis for DOX resistance.

Conclusions:

  • Long non-coding RNAs (lncRNAs) are critically involved in mediating doxorubicin (DOX) resistance.
  • lncRNAs hold promise as predictive biomarkers for patient response to DOX chemotherapy.
  • Targeting lncRNAs may offer novel therapeutic strategies to overcome DOX resistance and improve cancer patient outcomes.
Keywords:
CancerChemotherapyDoxorubicinDrug resistance

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